Added: Naisha Violette - Date: 02.08.2021 23:52 - Views: 40077 - Clicks: 3638
MDMA 3,4-methylenedioxy-N-methylamphetaminebetter known as "Ecstasy", is a synthetic drug with psychedelic and stimulant effects which has gained great popularity. It is closely tied to the underground scene, but has also been used therapeutically as an adjunct to psychotherapy. Both scientific as well as newspaper articles communicate faulty or incomplete information on the origin of MDMA and the role of the German pharmaceutical-chemical company Merck in its development. One of the most common misconceptions is that the substance was synthesized with the goal of creating an anorectic but was not marketed by Merck because of side effects.
An interdisciplinary working group conducted a comprehensive analysis of the original documents in Merck's historical archive in Darmstadt, Germany. It could be revealed that MDMA was in fact mentioned for the first time in files frombut not under this name. In the lab journals it was called "Methylsafrylamin". In a patent certificate it was mentioned only with its chemical structure. Merck applied for this patent to protect an alternative chemical method for synthesizing the styptic hydrastinine, not appetite suppressants.
MDMA was not the key substance in this patent, only a precursor. Archive documents revealed that Merck's scientists did not perform basic pharmacological tests with MDMA now called "Safrylmethylamin" before These tests were halted for economic reasons. In the s, primitive toxicological studies were conducted but MDMA was not tested in humans. Please enable it to take advantage of the complete set of features!
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Similar articles The origin of MDMA ecstasy revisited: the true story reconstructed from the original documents. Freudenmann RW, et al. PMID: PMID: German. Passie T, et al. J Psychoactive Drugs. Epub Mar 3. Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine. Dunlap LE, et al. ACS Chem Neurosci. Epub Why was ecstasy created Kuhlmann T. Psychiatr Prax. PMID: Review. See all similar articles. Cited by 4 articles Beyond ecstasy: Alternative entactogens to 3,4-methylenedioxymethamphetamine with potential applications in psychotherapy.
Oeri HE. J Psychopharmacol. Epub Sep Who has used internal company documents for biomedical and public health research and where did they find them? Wieland LS, et al. PLoS One. Curr Neuropharmacol. Developmental effects of 3,4-methylenedioxymethamphetamine: a review. Skelton MR, et al. Behav Pharmacol. Publication types Historical Article Actions. Review Actions.
MeSH terms Why was ecstasy created Actions. History, 19th Century Actions. History, 20th Century Actions. Humans Actions. Substances Hallucinogens Actions. N-Methyl-3,4-methylenedioxyamphetamine Actions. Copy Download.Why was ecstasy created
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The origin of MDMA (ecstasy) revisited: the true story reconstructed from the original documents