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From hungry to drowsy to paranoid, even friends sharing the same bud can have surprisingly different reactions to the herb. Women, for example, may be more sensitive to the intoxicating effects of THC and may develop tolerance more quickly as a result. Men, however, may be more likely to experience hunger from THC. There may even be instances when weed does not affect some people, at least when they consume cannabis in specific ways.
Did you know that chemicals in the cannabis plant hijack the landing sites for molecules that your body produces naturally? THC works by engaging special receptor sites on the surface of nerve and immune cells. These receptor sites, called cannabinoid receptors, are like the landing places for THC. When THC takes over these receptor sites, it prevents other molecules from binding in these locations. As it turns out, these cannabinoid receptors are abundant in several intriguing brain regions. They are rampant in the hypothalamus, which is a central region that is responsible for overseeing your metabolic rate, biological clock, hormonal production, and your internal thermostat.
Cannabinoid receptors are also abundant in the amygdala, which is responsible for processing memory, fear, and emotion. As the theory goes, when THC engages these brain regions, it stays locked into these cell receptors longer than the compounds that would otherwise be there naturally. Weed has no effect, one of the compounds that cannabis replaces in the body is an endocannabinoid called anandamide. When THC takes over for anandamide, you can expect long-lasting and more potent effects than the original endocannabinoid typically provides. Every human being has cannabinoid receptors.
For this reason, it is assumed that every person can experience at least some effect from cannabis. One of the most common reasons why some people may not experience the effects of cannabis is due to improper inhalation. Smoking is one of the most popular ways to consume the herb, though it can take a few tries for many new consumers to feel the active effects of cannabis.
If you do not properly inhale, then the active compounds in the plant will not successfully enter the lungs and absorb into the bloodstream. Unfortunately, coughing often follows the inhalation of cannabis smoke. Smoke vapor can be hot and irritating to the tissues of the mouth, throat, and lungs.
With practice, you will likely cough less and develop better control over your breath. Unlike inhaled cannabis, edibles and oral cannabis preparations must first be digested and metabolized before you can feel the effects. After absorption through the walls of the intestines, cannabis compounds like THC make their way into the liver. The liver is the primary detoxifying organ in the human body, tagging potential toxins and drugs by changing their chemical composition.
Most of the time, the liver converts active drugs into more inactive compounds. THC, however, is a little unique. This metabolite is often thought to be more potent than the original THC. For this reason, a high from an edible is often stronger and more incapacitating than your average bong hit. For some people, however, this may not be the case.
It is speculated that many people have genetic variations that may make them more or less efficient in breaking down drugs like THC. Some people may not always convert high levels of THC into its more active form. These people may not experience the psychoactive effects of edibles. Inhaled consumption methods, like smoking and vaporization, are likely preferable to these people. Some people with certain medical conditions, for example, consume the herb and feel more normal. Some researchers have hypothesized that many medical conditions may be caused by changes to the endocannabinoid system.
If this is Weed has no effect case, it is understandable that some patients with certain health conditions may not experience the psychoactive effects of cannabis Weed has no effect much as others. Of course, this is merely a hypothesis. Neurologist and medical researcher Dr. Ethan Russo thinks that some people may have what is called an endocannabinoid deficiency. Simply stated, your body is not producing enough anandamide or other endocannabinoid molecules. As mentioned above, when you inhale or eat the psychoactive plant, THC hijacks the cell receptor where human endocannabinoids would normally land.
By doing so, THC taps into a larger network called the endocannabinoid system. This system is the largest neurotransmitter network in the body, and it controls a variety of key bodily functions. Some of these functions include:. Russo theorizes that people with certain medical conditions may not produce enough of these endocannabinoids in the first place. Specifically, those with migraines, fibromyalgia, and IBS.
Some mental health conditions like post-traumatic stress disorder and bipolar disorder may also have some sort of endocannabinoid dysfunction. If this is the case, those with some of these conditions may experience cannabis a bit differently than others. So, the outcome of your high may be dependent on your endocannabinoid tone and health status in the first place. Shortly after Israeli chemist, Rafael Mechoulam discovered psychoactive THC, he decided to test it out on his friends. He invited them over for some cake and gave them each 10 mg of pure THC. And then? He recorded the. All of those who took THC were affected.
But, surprisingly, they were affected differently. These effects are all well-known today. People are differently affected. In one case, however, one of the participants got into an anxiety state. She felt, I believe, that her psychological guards [were] breaking down. With this simple experiment, Mechoulam figured out that cannabis can produce a variety of effects among different people. Here are the leading hypotheses so far. Your genes may influence how you experience cannabis. Recent research has shown that some with a certain genetic mutation in the AKT1 are more inclined to feel anxious, paranoid, and experience psychotic effects from cannabis.
Additional research has shown that genetics contribute to varying levels of cognitive function while high. Specifically, your genes might make you more likely to have memory impairment from THC than your smoking buddy. Yet another study found that some people may naturally have more endocannabinoids in circulation than other people, thanks to an awesome genetic mutation.
Apparently, about 20 percent of American adults have a genetic mutation that may increase the natural levels of circulating endocannabinoids in the body. Folks that have Weed has no effect genetic mutation are less prone to anxiety. These people are also thought to be less inclined to use or enjoy cannabis. They already blissed out naturally, so why bother smoking? Even with the uncertainty, the research so far has been fascinating.
Cannabis affects men and women differently. Men are more likely to get the munchies than the ladies. But, women are more sensitive to the herb overall. Further, hormones may have a strong role to play in how a person responds to THC. Is it that Weed has no effect of the month, ladies?
Well, that has an influence, too. THC, the primary psychoactive in the plant, engages in a close dance with estrogen. The effects of THC are expected to be most powerful in women after estrogen levels are at their peak. Some people are just going to be more sensitive to cannabis than others.
Do you know someone who drinks just one cup of coffee and is bouncing off the walls? What about someone who is drunk after two beers? People respond differently to all kinds of things. Cannabis is one of them. This is where the endocannabinoid system comes into play yet again. Several factors can influence the endocannabinoid system. Genetics, diet, stress, and lifestyle all contribute to how the endocannabinoid system works in every individual.
For a diet example, endocannabinoids are derived from fatty acids. If your diet is low in healthy fats, your endocannabinoid system may likely be out of whack. Your internal chemistry at any given moment can influence your high. Further, no two people are alike in terms of biochemistry. So, while we can expect some general trends from the herb, the experience is quite individual. The more you consume, the greater your tolerance. Someone who has never tried cannabis before will react differently to the same strain and dose.
Their body simply is not used to the sudden influx of plant cannabinoids. Well, there you have it! There are many reasons why cannabis affects each person differently. Your health, genetic makeup, and lifestyle all contribute to how you experience the herb. From bongs to rigglers, Higher Standards has a selection of stylish smokable glassware deed to meet your every need and budget…. Their names are almost identical yet their effects are not. Here's what makes this new member of the THC family different from the…. If you live here or are just passing by for a visit, here are the best dispensaries to help you stay elevated.
Consuming cannabis is a unique and unbeatable sensation, but getting it out of your system can be a problem, especially in certain…. Sun, surf, and candy that keeps you elevated. What more could you ask for? Photography by Kaya Blaze Kelley for Herb. Overall, cannabis affects everyone differently. What Causes A High? Photography by Jonathan Coward for Herb. Photography by Connor Fyfe for Herb. Here are a couple of simple directions that will help you inhale cannabis: Begin to inhale slowly through the mouth.
Inhale deeply into the lungs, feeling a belly expansion. This is a diaphragmatic breath. Pause slightly at the top of the inhale, but there is no need to hold in the inhalation. Exhale slowly with control. Some of these functions include: Appetite Sleep Pleasure Pain Mood Motor skills Russo theorizes that people with certain medical conditions may not produce enough of these endocannabinoids in the first place. Why Cannabis Affects Everyone Differently. Photo by Kaya Blaze Kelley for Herb.
Individual Biochemistry. Photo by Connor Fyfe for Herb. FAQ learn medical smoking. June 16, Written by Anna Wilcox. Save for later. The Latest. Weed, Delivered. Me Up! Articles for You.Weed has no effect
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